famotidine (Pepcid, Apogastine)

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Introduction

Tradename: Pepcid, Pepcid AC.

Indications

Dosage

Tabs: 10, 20 & 400 mg

Suspension: 40 mg/5 mL

Dosage adjustment in renal failure

Adverse effects

Toxicity:

  • no data on deliberate overdose
  • adults have been given up to 640 mg/day with no serious adverse effects[3]

Laboratory

More general terms

Component of

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Jump up to: 2.0 2.1 Prescriber's Letter 8(5):26 2001
  3. Jump up to: 3.0 3.1 3.2 3.3 Physician's Desk Reference (PDR) 56th edition, Medical Economics, 2002
  4. Jump up to: 4.0 4.1 Taha AS Famotidine for the prevention of peptic ulcers and oesophagitis in patients taking low-dose aspirin (FAMOUS): a phase III, randomised, double-blind, placebo-controlled trial. Lancet, Volume 374, Issue 9684, Pages 119-125, 11 July 2009 PMID: https://www.ncbi.nlm.nih.gov/pubmed/19577798
  5. Jump up to: 5.0 5.1 Deprecated Reference
  6. Jump up to: 6.0 6.1 6.2 6.3 A Pocket Guide to the 2019 Beer's Criteria. American Geriatrics Society.
  7. Jump up to: 7.0 7.1 Cohen E, Nigam M Study shows Covid-19 patients who took heartburn drug were less likely to die, but researchers caution more research is needed. CNN Health. May 9, 2020. https://www.cnn.com/2020/05/09/health/famotidine-covid-19-correlation-study/index.html
    Freedberg DE, Conigliaro J, Sobieszczyk ME et al Famotidine Use is Associated with Improved Clinical Outcomes in Hospitalized COVID-19 Patients: A Retrospective Cohort Study. medRxiv. May 8, 2020 Not indexed in PubMed https://www.medrxiv.org/content/10.1101/2020.05.01.20086694v1
    Freedberg DE, Conigliaro J, Wang TC et al Famotidine Use is Associated with Improved Clinical Outcomes in Hospitalized COVID-19 Patients: A Propensity Score Matched Retrospective Cohort Study. Gastroenterology. 2020 May 22:S0016-5085(20)34706-5 PMID: https://www.ncbi.nlm.nih.gov/pubmed/32446698 Free PMC article
    Walker M More Evidence Heartburn Drug May Help COVID-19 Patients - Another observational study adds fuel to the fire, but more research is needed. MedPage Today August 17, 2020 https://www.medpagetoday.com/infectiousdisease/covid19/88119
    Mather JF, Seip RL, McKay RG et al Impact of famotidine use on clinical outcomes of hospitalized COVID-19 patients. Am J Gastroenterol; August 26, 2020. PMID: https://www.ncbi.nlm.nih.gov/pubmed/32852338 https://journals.lww.com/ajg/Documents/AJG-20-2074_R1.pdf
    Swift D Common Heartburn Drug for COVID-19 Symptoms? In case series, non-hospitalized patients felt better within 1-2 days of starting famotidine MedPage Today. June 4, 2020 https://www.medpagetoday.com/infectiousdisease/covid19/86893
  8. Jump up to: 8.0 8.1 Cohen E After hopeful early signs, study of popular heartburn drug shows mixed results against Covid-19. CNN Health. Feb 10, 2022 https://www.cnn.com/2022/02/10/health/covid-famotidine-study-results/index.html
  9. Department of Veterans Affairs, VA National Formulary

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