stress ulcer prophylaxis

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Management

* significant GI bleeding is relatively rare in critically ill patients[3]

More general terms

Additional terms

References

  1. 1.0 1.1 Selvanderan SP1, Summers MJ, Finnis ME et al Pantoprazole or Placebo for Stress Ulcer Prophylaxis (POP-UP): Randomized Double-Blind Exploratory Study. Crit Care Med. 2016 Oct;44(10):1842-50 PMID: https://www.ncbi.nlm.nih.gov/pubmed/27635481
    Marik PE Stress Ulcer Prophylaxis Deadoption: What is the Barrier? PMID: https://www.ncbi.nlm.nih.gov/pubmed/27635486
  2. 2.0 2.1 Cook D, Guyatt G. Prophylaxis against Upper Gastrointestinal Bleeding in Hospitalized Patients. N Engl J Med 2018; 378:2506-2516. June 28, 2018 PMID: https://www.ncbi.nlm.nih.gov/pubmed/29949497 https://www.nejm.org/doi/full/10.1056/NEJMra1605507
  3. 3.0 3.1 3.2 Krag M, Marker S, Perner A et al. Pantoprazole in patients at risk for gastrointestinal bleeding in the ICU. N Engl J Med 2018 Oct 24; PMID: https://www.ncbi.nlm.nih.gov/pubmed/30354950 Free Article
    Barkun A, Bardou M. Proton-pump inhibitor prophylaxis in the ICU - Benefits worth the risks? N Engl J Med 2018 Oct 24; PMID: https://www.ncbi.nlm.nih.gov/pubmed/30354949 Free Article
  4. 4.0 4.1 Young PJ et al. Effect of stress ulcer prophylaxis with proton pump inhibitors vs histamine-2 receptor blockers on in-hospital mortality among ICU patients receiving invasive mechanical ventilation: The PEPTIC randomized clinical trial. JAMA 2020 Jan 17; PMID: https://www.ncbi.nlm.nih.gov/pubmed/31950977 https://jamanetwork.com/journals/jama/article-abstract/2759412
  5. 5.0 5.1 Wang Y et al. Efficacy and safety of gastrointestinal bleeding prophylaxis in critically ill patients: Systematic review and network meta-analysis. BMJ 2020 Jan 6; 368:l6744 PMID: https://www.ncbi.nlm.nih.gov/pubmed/31907166 https://www.bmj.com/content/368/bmj.l6744
  6. 6.0 6.1 Medical Knowledge Self Assessment Program (MKSAP) 19 American College of Physicians, Philadelphia 2022
  7. 7.0 7.1 NEJM Knowledge+ Gastroenterology