H2 receptor antagonist

^[1]^[2]^[3]^[4]

Adverse effects

some associated with delirium in the elderly^[1]
- strongest evidence associating cimetidine with delirium in the elderly^[1]
increased risk of hip fracture^[2]
- no increase in risk^[3]
use during the 1st 6 months of life associated with increased risk for food allergy during childhood (RR=2.2)^[4]

↑ ^1.0 ^1.1 ^1.2 Prescriber's Letter 19(7): 2012 H2-Blockers in the Elderly Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=280703&pb=PRL (subscription needed) http://www.prescribersletter.com
↑ ^2.0 ^2.1 Corley DA, Kubo A, Zhao W, Quesenberry C. Proton pump inhibitors and histamine-2 receptor antagonists are associated with hip fractures among at-risk patients. Gastroenterology 2010; 139(1):93-101. Epub 2010 Mar 27. PMID: https://www.ncbi.nlm.nih.gov/pubmed/20353792
↑ ^3.0 ^3.1 Eom CS, Park SM, Myung SK, Yun JM, Ahn JS. Use of acid-suppressive drugs and risk of fracture: a meta-analysis of observational studies. Ann Fam Med. 2011 May-Jun;9(3):257-67. doi:http://dx.doi.org/ 10.1370/afm.1243. PMID: https://www.ncbi.nlm.nih.gov/pubmed/21555754
↑ ^4.0 ^4.1 Mitre E, Susi A, Kropp LE, et al Association Between Use of Acid-Suppressive Medications and Antibiotics During Infancy and Allergic Diseases in Early Childhood. JAMA Pediatr. Published online April 2, 2018 PMID: https://www.ncbi.nlm.nih.gov/pubmed/29610864 https://jamanetwork.com/journals/jamapediatrics/fullarticle/2676167