drug adverse effects of H2-receptor antagonists
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Adverse effects
- increased risk of community-acquired pneumonia* (0.02%) risk may be greater for:
- elderly
- COPD
- asthma
- immunocompromised
- increased risk of hospital-acquired pneumonia[3][4]
- increased risk of necrotizing enterocolitis in very low birth weight infants
- increased risk of hip fracture[5]
- no increase in risk[6]
- use during the 1st 6 months of life associated with increased risk for food allergy during childhood (RR=2.2)[7]
- increased risk for allergy
* Low pH of stomach acid is antimicrobial. In the absence of acid, refluxed & aspirated gastric contents may contain pathogen that causes pneumonia.
More general terms
References
- ↑ Prescriber's Letter 11(12): 2004 Community-Acquired Pneumonia Risk with Acid-Suppressive Drugs Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=201207&pb=PRL (subscription needed) http://www.prescribersletter.com
- ↑ Laheij RJ, Sturkenboom MC, Hassing RJ, Dieleman J, Stricker BH, Jansen JB. Risk of community-acquired pneumonia and use of gastric acid- suppressive drugs. JAMA. 2004 Oct 27;292(16):1955-60. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15507580
- ↑ 3.0 3.1 Prescriber's Letter 16(7): 2009 Overuse of Acid Suppressing Drugs in the Hospital Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=250720&pb=PRL (subscription needed) http://www.prescribersletter.com
- ↑ Eom C-S et al. Use of acid-suppressive drugs and risk of pneumonia: Systematic review and meta-analysis. CMAJ 2010 Dec 20 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/21173070 <Internet> http://www.cmaj.ca/cgi/content/abstract/cmaj.092129v1
- ↑ 5.0 5.1 Corley DA, Kubo A, Zhao W, Quesenberry C. Proton pump inhibitors and histamine-2 receptor antagonists are associated with hip fractures among at-risk patients. Gastroenterology 2010; 139(1):93-101. Epub 2010 Mar 27. PMID: https://www.ncbi.nlm.nih.gov/pubmed/20353792
- ↑ 6.0 6.1 Eom CS, Park SM, Myung SK, Yun JM, Ahn JS. Use of acid-suppressive drugs and risk of fracture: a meta-analysis of observational studies. Ann Fam Med. 2011 May-Jun;9(3):257-67. doi:http://dx.doi.org/ 10.1370/afm.1243. PMID: https://www.ncbi.nlm.nih.gov/pubmed/21555754
- ↑ 7.0 7.1 Mitre E, Susi A, Kropp LE, et al Association Between Use of Acid-Suppressive Medications and Antibiotics During Infancy and Allergic Diseases in Early Childhood. JAMA Pediatr. Published online April 2, 2018 PMID: https://www.ncbi.nlm.nih.gov/pubmed/29610864 https://jamanetwork.com/journals/jamapediatrics/fullarticle/2676167
- ↑ Jordakieva G, Kundi M, Untersmayr E et al Country-wide medical records infer increased allergy risk of gastric acid inhibition. Nature Communications. volume 10, Article number: 3298 (2019) PMID: https://www.ncbi.nlm.nih.gov/pubmed/31363098 Free PMC Article https://www.nature.com/articles/s41467-019-10914-6