aspirin/codeine (Empirin with Codeine)

Introduction

DEA-controlled substance: class 3.

Contraindications

Avoid use with severe liver disease

pregnancy-category D

safety in lactation -

Dosage

#2: (325 mg aspirin + 15 mg codeine)

#3: (325 mg aspirin + 30 mg codeine).

#4: (325 mg aspirin + 60 mg codeine)

• 1-2 tabs PO every 4 hours. Dosage adjustment with renal failure:

creatinine clearance	dosage
10-50 mL/min	75% of dose
< 10 mL/min	avoid use

Pharmacokinetics

elimination: liver > kidney

More general terms

• narcotic combination

Components

• aspirin (Ecotrin, Empirin, Bayer aspirin, Vazalore, ASA)
• codeine

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3081774