aspirin/codeine (Empirin with Codeine)

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Introduction

DEA-controlled substance: class 3.

Contraindications

Avoid use with severe liver disease

pregnancy-category D

safety in lactation -

Dosage

#2: (325 mg aspirin + 15 mg codeine)

#3: (325 mg aspirin + 30 mg codeine).

#4: (325 mg aspirin + 60 mg codeine)

  • 1-2 tabs PO every 4 hours. Dosage adjustment with renal failure:
creatinine clearance dosage
10-50 mL/min 75% of dose
< 10 mL/min avoid use

Pharmacokinetics

elimination: liver > kidney

More general terms

Components

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Kaiser Permanente Northern California Regional Drug Formulary, 1998

Database