nasal polyps with asthma; aspirin-exacerbated respiratory disease; Samter syndrome
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Pathology
- mucosal swelling of the sinuses & nasal membranes
- formation of nasal polyps
- asthma precipitated by exposure to cyclooxygenase-1[4]
Clinical manifestations
- nasal polyps
- asthma & rhinosinusitus precipitated by exposure to aspirin or other NSAID[4]
- aspirin sensitivity
Management
- avoid aspirin, NSAIDs
- stepped asthma care, including leukotriene receptor antagonist[4]
Notes
- COX2 inhibitors may be better tolerated than non-selective NSAIDs
More general terms
Additional terms
References
- ↑ Morales DR et al. Safety risks for patients with aspirin-exacerbated respiratory disease after acute exposure to selective nonsteroidal anti-inflammatory drugs and COX-2 inhibitors: Meta-analysis of controlled clinical trials. J Allergy Clin Immunol 2014 Jul; 134:40 PMID: https://www.ncbi.nlm.nih.gov/pubmed/24388008
- ↑ White AA, Stevenson DD Aspirin-Exacerbated Respiratory Disease. N Engl J Med 2018; 379:1060-1070 PMID: https://www.ncbi.nlm.nih.gov/pubmed/30207919 https://www.nejm.org/doi/full/10.1056/NEJMra1712125
- ↑ Ledford DK, Wenzel SE, Lockey RF. Aspirin or other nonsteroidal inflammatory agent exacerbated asthma. J Allergy Clin Immunol Pract. 2014 Nov-Dec;2(6):653-7. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/25439353
- ↑ 4.0 4.1 4.2 4.3 Medical Knowledge Self Assessment Program (MKSAP) 19 American College of Physicians, Philadelphia 2022
Medical Knowledge Self Assessment Program (MKSAP) 19 Board Basics. An Enhancement to MKSAP19. American College of Physicians, Philadelphia 2022