celecoxib (Celebrex)

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Introduction

Tradename: Celebrex. Molecular formula: C17H14F3N3O2S.

1st generic FDA-approved May 30, 2014[14]

Indications

Contraindications

Dosage

Tabs: 100 & 200 mg.

Pharmacokinetics

elimination via liver

1/2life = 11-16 hours

protein binding = 97 %

Monitor

Adverse effects

Drug interactions

Laboratory

Mechanism of action

More general terms

Additional terms

Component of

References

  1. Searle-Pfizer package insert
  2. Prescriber's Letter 7(2):11, Feb. 2000
  3. 3.0 3.1 3.2 Prescriber's Letter 7(10):55 2000
  4. Prescriber's Letter 13(3): 2006 Cytochrome P450 drug interactions Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=220233&pb=PRL (subscription needed) http://www.prescribersletter.com
  5. 5.0 5.1 Prescriber's Letter 8(11):61 2001
  6. 6.0 6.1 6.2 6.3 Prescriber's Letter 9(5):26 2002
  7. 7.0 7.1 Prescriber's Letter 11(7):42 2004 Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=200702&pb=PRL (subscription needed) http://www.prescribersletter.com
  8. 8.0 8.1 Journal Watch 24(14):109, 2004 Mamdani M, Juurlink DN, Lee DS, Rochon PA, Kopp A, Naglie G, Austin PC, Laupacis A, Stukel TA. Cyclo-oxygenase-2 inhibitors versus non-selective non-steroidal anti-inflammatory drugs and congestive heart failure outcomes in elderly patients: a population-based cohort study. Lancet. 2004 May 29;363(9423):1751-6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15172772
  9. 9.0 9.1 9.2 Associated Press, Netscape 12/17/04 sites NCI study conducted for Pfizer
  10. 10.0 10.1 Prescriber's Letter 13(10): 2006 Cardiovascular Risks of NSAIDs and COX-2 Inhibitors Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=221003&pb=PRL (subscription needed) http://www.prescribersletter.com
  11. 11.0 11.1 Prescriber's Letter 17(7): 2010 Recommended Lab Monitoring for Common Medications Liver Function Test Scheduling Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=260704&pb=PRL (subscription needed) http://www.prescribersletter.com
  12. Cryer B et al. GI-REASONS: A novel 6-month, prospective, randomized, open-label, blinded endpoint (PROBE) trial. Am J Gastroenterol 2013 Mar; 108:392. PMID: https://www.ncbi.nlm.nih.gov/pubmed/23399552
  13. 13.0 13.1 Medical Knowledge Self Assessment Program (MKSAP) 16 American College of Physicians, Philadelphia 2012
  14. 14.0 14.1 FDA News Release. May 30, 2014 FDA approves first generic versions of celecoxib. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm399428.htm
  15. 15.0 15.1 15.2 Nissen SE, Yeomans ND, Solomon DH et al Cardiovascular Safety of Celecoxib, Naproxen, or Ibuprofen for Arthritis. N Engl J Med. Nov 13, 2016 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/27959716 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMoa1611593
    FitzGerald GA. ImPRECISION: Limitations to interpretation of a large randomized clinical trial. Circulation 2016 Nov 13; <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/27840335 <Internet> http://circ.ahajournals.org/content/early/2016/11/11/CIRCULATIONAHA.116.026324
  16. 16.0 16.1 Therapeutics Letter #108. Therapeutics Initiative Drugs to Avoid. http://www.ti.ubc.ca/2018/01/04/108-drugs-avoid/
  17. 17.0 17.1 Elia J, Sadoughi S, Saitz R. Celecoxib Gets Partial Exoneration from FDA Panels Physician's First Watch, April 26, 2018 David G. Fairchild, MD, MPH, Editor-in-Chief Massachusetts Medical Society http://www.jwatch.org
    Stein R Celebrex As Safe As Ibuprofen And Naproxen, FDA Advisers Say. Health News from NPR. April 25, 2018 https://www.npr.org/sections/health-shots/2018/04/25/605226604/fda-panel-affirms-safety-of-painkiller-celebrex

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