celecoxib (Celebrex)

From Aaushi
Jump to navigation Jump to search

Introduction

Tradename: Celebrex. Molecular formula: C17H14F3N3O2S.

1st generic FDA-approved May 30, 2014[14]

Indications

Contraindications

Dosage

Tabs: 100 & 200 mg.

Pharmacokinetics

elimination via liver

1/2life = 11-16 hours

protein binding = 97 %

Monitor

Adverse effects

Drug interactions

Laboratory

Mechanism of action

More general terms

Additional terms

Component of

References

  1. Searle-Pfizer package insert
  2. Prescriber's Letter 7(2):11, Feb. 2000
  3. Jump up to: 3.0 3.1 3.2 Prescriber's Letter 7(10):55 2000
  4. Prescriber's Letter 13(3): 2006 Cytochrome P450 drug interactions Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=220233&pb=PRL (subscription needed) http://www.prescribersletter.com
  5. Jump up to: 5.0 5.1 Prescriber's Letter 8(11):61 2001
  6. Jump up to: 6.0 6.1 6.2 6.3 Prescriber's Letter 9(5):26 2002
  7. Jump up to: 7.0 7.1 Prescriber's Letter 11(7):42 2004 Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=200702&pb=PRL (subscription needed) http://www.prescribersletter.com
  8. Jump up to: 8.0 8.1 Journal Watch 24(14):109, 2004 Mamdani M, Juurlink DN, Lee DS, Rochon PA, Kopp A, Naglie G, Austin PC, Laupacis A, Stukel TA. Cyclo-oxygenase-2 inhibitors versus non-selective non-steroidal anti-inflammatory drugs and congestive heart failure outcomes in elderly patients: a population-based cohort study. Lancet. 2004 May 29;363(9423):1751-6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15172772
  9. Jump up to: 9.0 9.1 9.2 Associated Press, Netscape 12/17/04 sites NCI study conducted for Pfizer
  10. Jump up to: 10.0 10.1 Prescriber's Letter 13(10): 2006 Cardiovascular Risks of NSAIDs and COX-2 Inhibitors Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=221003&pb=PRL (subscription needed) http://www.prescribersletter.com
  11. Jump up to: 11.0 11.1 Prescriber's Letter 17(7): 2010 Recommended Lab Monitoring for Common Medications Liver Function Test Scheduling Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=260704&pb=PRL (subscription needed) http://www.prescribersletter.com
  12. Cryer B et al. GI-REASONS: A novel 6-month, prospective, randomized, open-label, blinded endpoint (PROBE) trial. Am J Gastroenterol 2013 Mar; 108:392. PMID: https://www.ncbi.nlm.nih.gov/pubmed/23399552
  13. Jump up to: 13.0 13.1 Medical Knowledge Self Assessment Program (MKSAP) 16 American College of Physicians, Philadelphia 2012
  14. Jump up to: 14.0 14.1 FDA News Release. May 30, 2014 FDA approves first generic versions of celecoxib. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm399428.htm
  15. Jump up to: 15.0 15.1 15.2 Nissen SE, Yeomans ND, Solomon DH et al Cardiovascular Safety of Celecoxib, Naproxen, or Ibuprofen for Arthritis. N Engl J Med. Nov 13, 2016 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/27959716 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMoa1611593
    FitzGerald GA. ImPRECISION: Limitations to interpretation of a large randomized clinical trial. Circulation 2016 Nov 13; <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/27840335 <Internet> http://circ.ahajournals.org/content/early/2016/11/11/CIRCULATIONAHA.116.026324
  16. Jump up to: 16.0 16.1 Therapeutics Letter #108. Therapeutics Initiative Drugs to Avoid. http://www.ti.ubc.ca/2018/01/04/108-drugs-avoid/
  17. Jump up to: 17.0 17.1 Elia J, Sadoughi S, Saitz R. Celecoxib Gets Partial Exoneration from FDA Panels Physician's First Watch, April 26, 2018 David G. Fairchild, MD, MPH, Editor-in-Chief Massachusetts Medical Society http://www.jwatch.org
    Stein R Celebrex As Safe As Ibuprofen And Naproxen, FDA Advisers Say. Health News from NPR. April 25, 2018 https://www.npr.org/sections/health-shots/2018/04/25/605226604/fda-panel-affirms-safety-of-painkiller-celebrex

Database