drug adverse effects of sulfonamides
Jump to navigation
Jump to search
Adverse effects
- hypersensitivity*
- use during pregnancy associated with birth defects, including:
- anencephaly
- left-sided heart defects
- precipitation of acute intermittent porphyria[4]
* PEN-FAST (SULF-FAST) criteria for predicting sulfonamide hypersensitivity
- allergic event occurred <+ 5 years ago (2 points)
- event was anaphylaxis/angioedema or severe cutaneous adverse reaction (2 points)
- treatment was required for allergic event (1 point)
* a PEN-FAST (SULF-FAST) of <3 associated with <5% risk of hypersensitivity reaction
- a score >= 3 associated with >20% risk of hypersensitivity reaction[2]
More general terms
References
- ↑ Crider KS et al Antibacterial Medication Use During Pregnancy and Risk of Birth Defects. National Birth Defects Prevention Study Arch Pediatr Adolesc Med. 2009;163(11):978-985 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/19884587 <Internet> http://archpedi.ama-assn.org/cgi/content/short/163/11/978
- ↑ 2.0 2.1 Waldron JL et al. Development and validation of a sulfa antibiotic allergy clinical decision rule. JAMA Netw Open 2023 Jun 5; 6:e2316776. PMID: https://www.ncbi.nlm.nih.gov/pubmed/37273210 PMCID: PMC10242418 Free PMC article https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2805577
- ↑ NEJM Knowledge+
- ↑ Cite error: Invalid
<ref>tag; no text was provided for refs namedref13