sulfa allergy

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Epidemiology

Clinical manifestations

* PEN-FAST (SULF-FAST) criteria for predicting sulfonamide hypersensitivity[6]

* a PEN-FAST (SULF-FAST) of <3 associated with <5% risk of hypersensitivity reaction

Management

* Sulfonamide antibiotic reactions probably confer increased risk for drug reaction with non-antibiotic sulfonamides as a result of increased susceptibility to drug reactions rather than cross-reactivity of sulfonamides[2]

More general terms

Additional terms

References

  1. Prescriber's Letter 7(7):37 2000
  2. 2.0 2.1 Strom BL et al, N Engl J Med 349:1628, 2003 PMID: https://www.ncbi.nlm.nih.gov/pubmed/14573734
  3. 3.0 3.1 Prescriber's Letter 11(7):42 2004 Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=200702&pb=PRL (subscription needed) http://www.prescribersletter.com
  4. 4.0 4.1 4.2 4.3 Prescriber's Letter 11(7):42 2004 Sulfa Drugs and the Sulfa-allergic Patient Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=211113&pb=PRL (subscription needed) http://www.prescribersletter.com
  5. 5.0 5.1 NEJM Knowledge+ Endocrinology
  6. 6.0 6.1 6.2 Waldron JL et al. Development and validation of a sulfa antibiotic allergy clinical decision rule. JAMA Netw Open 2023 Jun 5; 6:e2316776. PMID: https://www.ncbi.nlm.nih.gov/pubmed/37273210 PMCID: PMC10242418 Free PMC article https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2805577
  7. 7.0 7.1 NEJM Knowledge+ Allergy/Immunology
    Dorn JM, Alpern M, McNulty C, Volcheck GW. Sulfonamide Drug Allergy. Curr Allergy Asthma Rep. 2018 Jun 6;18(7):38. PMID: https://www.ncbi.nlm.nih.gov/pubmed/29876667 Review.
    Khan DA, Knowles SR, Shear NH. Sulfonamide Hypersensitivity: Fact and Fiction. J Allergy Clin Immunol Pract. 2019 Sep-Oct;7(7):2116-2123. PMID: https://www.ncbi.nlm.nih.gov/pubmed/31495421 Review.