indapamide (Lozol)
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Introduction
Tradename: Lozol.
Indications
- management of mild to moderate hypertension
- treatment of edema
Dosage
Tabs: 1.25, 2.5 mg
Adverse effects
- not common (1-10%)
- uncommon (< 1%)
- arrhythmia, weak pulse, hypotension, mood changes, photosensitivity, fluid & electrolyte imbalances (hypocalcemia, hypomagnesemia, hyponatremia), hyperglycemia, pre-renal azotemia, shortness of breath, increased thirst, xerostomia, blood dyscrasias, muscle cramps, unusual weakness, paresthesia in hands, feet or lips
- other
* Appears to have less of an adverse effect on serum lipids than do other thiazides
- drug adverse effects of renin-angiotensin-aldosterone system inhibitors (RAAS inhibitors)
- drug adverse effects of thiazide diuretics
- drug adverse effects of diuretics
- drug adverse effects of antihypertensive agents
Mechanism of action
- enhances secretion of Na+, Cl- & H2O by interfering with Na+ & Cl- transport across the renal tubular epithelium mediated by SLC12A3
- site of action: distal tubule.
More general terms
References
- ↑ The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996.
- ↑ Manual of Medical Therapeutics, 28th ed, Ewald & McKenzie (eds), Little, Brown & Co, Boston, 1995, pg 123
- ↑ Kaiser Permanente Northern California Regional Drug Formulary, 1998
- ↑ Department of Veterans Affairs, VA National Formulary
restricted to nephrology/endocrinology