solute carrier family 12 member 3; thiazide-sensitive Na+Cl- cotransporter; Na+Cl- symporter (SLC12A3, TSC)

Function

• electrically silent transporter system
• mediates Na+ & chloride reabsorption
• principal mediator of Na+ & Cl- reabsorption in the distal convoluted tubule of the kidney

Structure

belongs to the SLC12A transporter family

Compartment

membrane

Expression

predominant in kidney

Pathology

• defects in SLC12A3 are the cause of Gitelman syndrome

Pharmacology

• inhibited by thiazide diuretics used in treatment of hypertension

More general terms

• symporter
• solute carrier family 12 (SLC12, SLC12A)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6559
• OMIM: https://mirror.omim.org/entry/263800
• OMIM: https://mirror.omim.org/entry/600968
• UniProt: http://www.uniprot.org/uniprot/P55017.html