captopril (Capoten)

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Introduction

Tradename: Capoten.

Indications

Dosage

Tabs: 12.5, 25, 50, 100 mg.

Pharmacokinetics

elimination via liver

elimination via kidney

1/2life = 6-8 hours

1/2life = 1.7 hours

Adverse effects

* side effects of angioedema & agranulocytosis may be more common in captopril than in other ACE inhibitors because of sulfhydryl group, especially in patients with connective tissue disease or serum creatinine > 1.5 mg/dL

Drug interactions

Mechanism of action

Notes

More general terms

Additional terms

Component of

References

  1. Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1990. pg 760-1
  2. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  3. Manual of Medical Therapeutics, 28th ed, Ewald & McKenzie (eds), Little, Brown & Co, Boston, 1995, pg 117
  4. 4.0 4.1 Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  5. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  6. 6.0 6.1 Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 470
  7. 7.0 7.1 Deprecated Reference
  8. 8.0 8.1 8.2 8.3 Medical Knowledge Self Assessment Program (MKSAP) 17, American College of Physicians, Philadelphia 2015
  9. 9.0 9.1 NEJM Knowledge+ Question of the Week. Sept 18, 2018 https://knowledgeplus.nejm.org/question-of-week/15/

Database