Captopril Prevention Project (CAPPP)

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Introduction

The study tested the effect of the ACE inhibitor captopril in 11,000 patients in Sweden & Finland. Patients received either captopril & a diuretic if necessary or diuretics, beta-blocker or both. During an average follow-up of 6 years, there were no difference in the group in the frequency of myocardial infarction or stroke.

In a subset of 572 diabetic patients with diastolic blood pressure > 100 mm Hg

Combined endpoint:

Results:

combined endpoint less freatuent in captopril group adjusted relative risk 0.59
no difference in risk of stroke
myocardial infarction less frequent in captopril group adjusted relative risk 0.34

↑ Journal Watch 22(2):13, 2002 Niskanen L et al Reduced cardiovascular morbidity and mortality in hypertensive diabetic patients on first-lin therapy with and ACE inhibitor compared with a diuretic/beta-blocker-based treatment regimen: a subanalysis of the Captopril Prevention Project. Diabetes Care 24:2091, 2001 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11723089