serine/threonine protein kinase B-raf; proto-oncogene B-Raf; p94; v-Raf murine sarcoma viral oncogene homolog B1 (BRAF BRAF1 RAFB1)

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Function

Cofactor: binds two Zn+2 per subunit (putative)

Structure

Compartment

cytoplasm

Expression

brain & testis

Pathology

Laboratory

More general terms

References

  1. UniProt http://www.uniprot.org/uniprot/P15056.html
  2. Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org/genes/BRAFID828.html
  3. GeneReviews http://www.ncbi.nlm.nih.gov/sites/genetests/lab/gene/BRAF
  4. Stephens RM, Sithanandam G, Copeland TD, Kaplan DR, Rapp UR, Morrison DK. 95-kilodalton B-Raf serine/threonine kinase: identification of the protein and its major autophosphorylation site. Mol Cell Biol. 1992 Sep;12(9):3733-42. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1508179
  5. Vojtek AB, Hollenberg SM, Cooper JA. Mammalian Ras interacts directly with the serine/threonine kinase Raf. Cell. 1993 Jul 16;74(1):205-14. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8334704
  6. 6.0 6.1 Journal Watch 22(16):128, 2002 Davies H et al Mutations of the BRAF gene in human cancer. Nature 417:949, 2002 PMID: https://www.ncbi.nlm.nih.gov/pubmed/12068308
    Pollock PM, Meltzer PS. Lucky draw in the gene raffle. Nature. 2002 Jun 27;417(6892):906-7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/12087387
    Dong J, et al BRAF oncogenic mutations correlate with progression rather than initiation of human melanoma. Cancer Res. 2003 Jul 15;63(14):3883-5. PMID: https://www.ncbi.nlm.nih.gov/pubmed/12873977
    Pollock PM & Meltzer PS, A genome-based strategy uncovers frequent BRAF mutations in melanoma. Cancer Cell. 2002 Jul;2(1):5-7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/12150818

Database