LEOPARD syndrome (Moynahan's syndrome, multiple lentigenes syndrome)

Introduction

The acronym LEOPARD stands for lentigines, electrocardiographic conduction abnormalities, ocular hypertelorism, pulmonic stenosis, abnormalities of genitalia, retardation of growth, & deafness

Pathology

• multiple lentigines, basal cell nevi
• electrocardiographic changes
• ocular hypertelorism
• pulmonary stenosis
• abnormal genitalia
• retardation of growth
• deafness
• broad facies
• rib anomalies

Genetics

• associated with defects in PTPN11
• associated with defects in BRAF

More general terms

• developmental disorder syndrome (multisystem disorder)
• genetic syndrome (multisystem disorder)

Additional terms

• lentigo; melanocytic macule