transcription initiation factor TFIID subunit 9; RNA polymerase II TBP-associated factor subunit G; STAF31/32; transcription initiation factor TFIID 31 kD subunit; TAFII-31; TAFII31; transcription initiation factor TFIID 32 kD subunit; TAFII-32; TAFII32 (TAF9, TAF2G, TAFII31)

Function

• component of TFIID complex, TFTC-HAT complex, PCAF complex & the STAGA complex
• essential for cell viability
• TAF9 & TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes
• may have a role in gene regulation associated with apoptosis
• binds N-terminal domain of TP53/p53, essential for transcription
• binds TFIIB & the Herpes simplex virus activator VP16
• forms a heterodimer with TAF6/TAFII80 in a complex with the TAF4B/TAFII105-TAF12/TAFII20 heterodimer
• also interacts with TAF5
• binds directly DNA with increased DNA binding when complexed with TAF6/TAFII80

Structure

belongs to the TAF9 family

Compartment

nucleus

Expression

6 to 8-fold by apoptotic signals

More general terms

• transcription factor IID subunit
• DNA-binding protein
• phosphoprotein

Additional terms

• adenylate kinase isoenzyme 6; ATP-AMP transphosphorylase 6; coilin-interacting nuclear ATPase protein; hCINAP (TAF9, AK6, CINAP, AD-004, CGI-137)

Component of

• PCAF complex; coactivator for p53/TP53-dependent transcriptional activation; PCAF histone acetylase complex

Database

• OMIM: https://mirror.omim.org/entry/600822
• UniProt: http://www.uniprot.org/uniprot/Q16594.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6880