transcription initiation factor TFIID subunit 5; p100TFIID; transcription initiation factor TFIID 100 kD subunit; TAF(II)100; TAFII-100; TAFII100 (TAF5, TAF2D)

Function

• component of TFIID complex, PCAF complex & TFTC complex
• TAF5 interacts strongly with the histone H4-related TAF6 & the histone H3-related TAF9
• forms a stable complex with TAF6
• weaker interaction with TBP, TAF1, TAF11 & TAF12

Structure

• distinct domains of TAF5 are required for functional interaction with transcription factor TFIIFB (RAP30) & incorporation into the TFIID complex
• belongs to the WD repeat TAF5 family
• contains 1 LisH domain
• contains 6 WD repeats

Compartment

nucleus

Alternative splicing

named isoforms=2

More general terms

• transcription factor IID subunit
• WD repeat protein family

Component of

• transcription factor IID (TFIID)
• PCAF complex; coactivator for p53/TP53-dependent transcriptional activation; PCAF histone acetylase complex

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6877
• OMIM: https://mirror.omim.org/entry/601787
• UniProt: http://www.uniprot.org/uniprot/Q15542.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6877