transcription factor IIB; general transcription factor; S300-II (GTF2B, TF2B, TFIIB)
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Function
- general transcription factor
- required for transcription
- role in the activation of eukaryotic genes transcribed by RNA polymerase 2
- associates with TFIID-TFIIA (DA complex) to form TFIID-TFIIA-TFIIB (DAB-complex) which is then recognized by RNA polymerase 2
- interacts with the transcription elongation factor TCEA2
- interacts with HIV-1 Vpr
- interacts with GPBP1 (putative)
- in yeast, TFIIB associates with RNA polymerase 2, TFIIH, & the SRB subcomplex to form the RNA pol II holoenzyme
Cofactor: binds 1 Zn+2 per subunit
Structure
- belongs to the TFIIB family
- contains 1 TFIIB-type Zn+2 finger
Compartment
More general terms
- general transcription factor (basal transcription factor, transcription initiation factor)
- adenosine triphosphatase (ATPase)
Component of
References
- ↑ Molecular Cell Biology (2nd ed) Darnell J; Lodish H & Baltimore D (eds), Scientific American Books, WH Freeman, NY 1990, pg 294
- ↑ Ha I, Lane WS, Reinberg D. Cloning of a human gene encoding the general transcription initiation factor IIB. Nature. 1991 Aug 22;352(6337):689-95. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1876184
- ↑ Buratowski S. The basics of basal transcription by RNA polymerase II. Cell. 1994 Apr 8;77(1):1-3. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8156586
- ↑ UniProt http://www.uniprot.org/uniprot/Q00403.html