transcription elongation factor A protein 2 (transcription elongation factor S-II protein 2, transcription elongation factor TFIIS.i, TCEA2 TFIIS.i)
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Function
- facilitates RNA polymerase 2 transcription elongation past template-encoded arresting sites
- arresting sites trap some of the elongating RNA polymerase, resulting in block of transcription
- cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'terminus.