transcription initiation factor TFIID subunit 4B; p105TFIID; transcription initiation factor TFIID 105 kD subunit; TAF(II)105; TAFII-105; TAFII105 (TAF4B, TAF2C2, TAFII105)

Function

• cell type-specific subunit of TFIID
• may function as a gene-selective coactivator in certain cells
• TAFII105 is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit
• involved in the activation of a subset of antiapoptotic genes including TNFAIP3
• may be involved in regulating folliculogenesis
• through interaction with OCBA/POU2AF1, acts as a coactivator of B cell-specific transcription
• heterodimerizes with TAF12 via the C-terminal H2A-like histone-fold domain; this heterodimer forms a histone-like octamer with the TAF6-TAF9 heterodimer
• interacts with P65/RELA homodimers & RELA-REL heterodimers
• interaction with POU2AF1, via C-terminal activation domain, is required for octamer-dependent transcription
• under stimulation by forskolin, isoform 1 is phosphorylated by protein kinase A (PKA)

Structure

• belongs to the TAF4 family
• contains 1 histone-fold domain
• contains 1 TAFH (NHR1) domain

Compartment

• nucleus, cytoplasm.
• export into the cytoplasm is mediated by a CRM1-independent nuclear export pathway & not by phosphorylation

Alternative splicing

named isoforms=2

Expression

• preferentially expressed in ovarian granulosa cells (at protein level)
• highly expressed in B cells

More general terms

• transcription factor IID subunit
• phosphoprotein

Component of

• transcription factor IID (TFIID)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6875
• OMIM: https://mirror.omim.org/entry/601689
• UniProt: http://www.uniprot.org/uniprot/Q92750.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6875