PHD finger protein 20 (hepatocellular carcinoma-associated antigen 58, glioma-expressed antigen 2, transcription factor TZP, novel zinc finger protein, PHF20, C20orf104, GLEA2, HCA58, NZ,F TZP)

Function

transcription factor (putative)

Structure

• contains 1 A.T hook DNA-binding domain
• contains 1 C2H2-type zinc finger
• contains 1 PHD-type zinc finger

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

• expressed in heart, kidney, liver, lung, pancreas, placenta, spleen, testis
• not expressed in brain, skeletal muscle, colon, ovary, prostate, small intestine, thymus

Pathology

• expressed in colon & ovarian cancer cell line, but not expressed in respective normal tissues
• antibodies against PHF20 are present in sera from patients with hepatocellular carcinoma, glioblastoma* & childhood medulloblastula

* may serve as diagnostic marker in glioblastoma

More general terms

• C2H2 type zinc finger protein
• transcription factor (TF)

Database

• UniProt: http://www.uniprot.org/uniprot/Q9BVI0.html