17 beta-hydroxysteroid dehydrogenase-8 (estradiol 17-beta-dehydrogenase 8, 17-beta-HSD 8, protein Ke6, Ke-6, HSD17B8, FABGL, HKE6, RING2, D6S2245E)

Function

• estrogens biosynthesis
• uses estradiol as its preferred substrate

estradiol-17-beta + NAD(P)(+)  <-->  estrone +  NADPH

Expression

• expressed in liver, pancreas > skeletal muscle, kidney

More general terms

• 17 beta-hydroxysteroid dehydrogenase

Database

• OMIM: https://mirror.omim.org/entry/601417
• UniProt: http://www.uniprot.org/uniprot/Q92506.html