sentrin-specific protease 3; SUMO-1-specific protease 3; sentrin/SUMO-specific protease SENP3 (SENP3, SSP3, SUSP3)

Function

• protease that releases SUMO2 & SUMO3 monomers from sumoylated substrates, but has only weak activity with SUMO1 conjugates
• deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability
• deconjugates SUMO2 & SUMO3 from CDCA8
• redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300
• required for rRNA processing through deconjugation of SUMO2 & SUMO3 from nucleophosmin, NPM1
• on oxidative stress, SENP3 degradation is blocked by inhibition of its ubiquitination, which stabilizes it as it accumulates in the nucleoplasm
• binds to SUMO1 & SUMO3 (putative)
• component of some MLL1/MLL complex
• interacts with EP300, NPM1 & CDCA8

Structure

• belongs to the peptidase C48 family

Compartment

• nucleus, nucleolus, nucleoplasm
• redistributes between the nucleolus & the nucleoplasm in response to mild oxidative stress

More general terms

• sentrin-specific protease (SUMO-specific protease)
• nuclear protein
• phosphoprotein

Additional terms

• small ubiquitin-related modifier 1; SUMO-1; sentrin; ubiquitin-like protein SMT3C; SMT3 homolog 3; ubiquitin-homology domain protein PIC1; ubiquitin-like protein UBL1; GAP-modifying protein 1; GMP1 (SUMO1, SMT3C, SMT3H3, UBL1, OK/SW-cl43)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=26168
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:26168
• OMIM: https://mirror.omim.org/entry/612844
• UniProt: http://www.uniprot.org/uniprot/Q9H4L4.html