MAX gene-associated protein (MGA KIAA0518)

Function

• dual-specificity transcription factor
• regulaties expression of both MAX-network & T-box family target genes
• functions as a repressor or an activator
• binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence & seems to regulate MYC-MAX target genes
• suppresses transcriptional activation by MYC & inhibits MYC-dependent cell transformation
• function activated by heterodimerization with MAX
• heterodimerization serves the dual function of both generating an E-box-binding heterodimer & simultaneously blocking interaction of a corepressor
• interacts with MAX
• requires dimerization with MAX for E-box binding (putative)

Structure

• transcription repression is enhanced or dependent on the presence of the T-box DNA-binding domain (putative)
• contains 1 basic helix-loop-helix (bHLH) domain
• contains 1 T-box DNA-binding domain

Compartment

nucleus (probable)

Alternative splicing

named isoforms=2

More general terms

• phosphoprotein
• DNA-binding protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8IWI9.html