transcription initiation factor TFIID subunit 7; RNA polymerase II TBP-associated factor subunit F; transcription initiation factor TFIID 55 kD subunit; TAF(II)55; TAFII-55; TAFII55 (TAF7, TAF2F, TAFII55)

Function

• component of TFIID, both TFIID-alpha & TFIID beta (see TFIID)
• p55TFIID may be a co-activator that mediates transcriptional activation in response to Sp1, YY1, USF, adenoviral E1A, HIV-1 Tat, & other transcriptional activators
• interacts with TAFII250, TAFII100, TAFII28, TAFII20, & TAFII18, but not with TAFII30 or TBP

Structure

• the [KR]-[STA]-K motif is specifically recognized by the SETD7 methyltransferase, which methylates Lys-5 in vitro
• belongs to the TAF7 family
• contains consensus sites for phosphorylation by PKC, cAMP protein kinase & casein kinase 2

Compartment

nucleus

Expression

ubiquitous

More general terms

• transcription factor IID subunit
• phosphoprotein

Component of

• transcription factor IID (TFIID)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6879
• OMIM: https://mirror.omim.org/entry/600573
• UniProt: http://www.uniprot.org/uniprot/Q15545.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6879