upstream stimulatory factor 1; class B basic helix-loop-helix protein 11; bHLHb11; major late transcription factor 1 (USF1, BHLHB11, USF)

Function

• transcription factor & DNA-binding protein
• binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3' found in a variety of viral & cellular promoters
• efficient DNA binding requires dimerization with another bHLH protein
• binds DNA as an homodimer or a heterodimer (USF1/USF2)
• interacts with varicella-zoster virus IE62 protein

Structure

contains 1 basic helix-loop-helix (bHLH) domain

Compartment

nucleus

Pathology

• genetic variations in USF1 are associated with combined hyperlipidemia type 1

More general terms

• basic helix loop helix (bHLH) family transcription factor

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7391
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7391
• OMIM: https://mirror.omim.org/entry/144250
• OMIM: https://mirror.omim.org/entry/191523
• OMIM: https://mirror.omim.org/entry/602491
• UniProt: http://www.uniprot.org/uniprot/P22415.html