transcription initiation factor TFIID subunit 10; STAF28; transcription initiation factor TFIID 30 kD subunit; TAF(II)30; TAFII-30; TAFII30 (TAF10, TAF2A, TAF2H, TAFII30)

Function

• component of TFIID complex, PCAF histone acetylase complex & TBP-free TAFII complex (TFTC)
• interacts with TAF3
• monomethylated at Lys-189 by SETD7, leading to increase its affinity for RNA polymerase 2

Structure

• [KR]-[STA]-K motif is specifically recognized by the SETD7 methyltransferase
• belongs to the TAF10 family

Compartment

nucleus

More general terms

• transcription factor IID subunit

Component of

• PCAF complex; coactivator for p53/TP53-dependent transcriptional activation; PCAF histone acetylase complex
• TFTC-HAT complex (TATA-binding protein-free TAF complex, TBP-free TAFII complex, TFTC)
• STAGA transcription coactivator-HAT complex
• transcription factor IID (TFIID)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6881
• OMIM: https://mirror.omim.org/entry/600475
• UniProt: http://www.uniprot.org/uniprot/Q12962.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6881