transcriptional repressor protein YY1; Yin & yang 1; YY-1; delta transcription factor; NF-E1 (YY1)

Function

• multifunctional transcription factor
• positive & negative control on a large number of cellular & viral genes through binding to sites overlapping the transcription start site
• role in development & differentiation
• function of YY1 as an activator or a repressor is specified by the presence of other proteins; acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence
• interacts with YAF2 through the region encompassing the first & second Zn+2 fingers

Structure

• belongs to the YY transcription factor family
• contains 4 C2H2-type Zn+2 fingers

Compartment

• nuclear matrix
• associated with the nuclear matrix

More general terms

• transcriptional silencer (transcriptional repressor)
• C2H2 type zinc finger protein
• phosphoprotein

Additional terms

• YY1 gene mutation

Database

• UniProt: http://www.uniprot.org/uniprot/P25490.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7528
• OMIM: https://mirror.omim.org/entry/600013
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7528