YY1-associated factor 2 (YAF2)

Function

• binds to MYC & inhibits MYC-mediated transactivation
• binds to MYCN & enhances MYCN-dependent transcriptional activation
• increases calpain 2-mediated proteolysis of YY1 in vitro
• component of the E2F6.com-1 complex
• interacts with MYC, MYCN, RNF2/RING1B & YY1

Structure

• contains 1 RanBP2-type zinc finger

Compartment

nucleus

Alternative splicing

named isoforms=2

More general terms

• transcriptional silencer (transcriptional repressor)
• transcription factor (TF)
• zinc finger protein

Component of

• E2F6.com-1 complex

Database

• OMIM: https://mirror.omim.org/entry/607534
• UniProt: http://www.uniprot.org/uniprot/Q8IY57.html