E3 ubiquitin-protein ligase RING2; Huntingtin-interacting protein 2-interacting protein 3; HIP2-interacting protein 3; protein DinG; RING finger protein 1B; RING1b; RING finger protein 2; RING finger protein BAP-1 (RNF2, BAP1, DING, HIPI3, RING1B)

Function

• E3 ubiquitin ligase protein, ubiquitin conjugation, 3rd step
• mediates monoubiquitination of Lys-119 of histone H2A
• X chromosome inactivation of female mammals
• initiation of both imprinted & random X inactivation
• component of Polycomb group multiprotein PRC1 complex
• component of: PCR1 complex, E2F6.com-1 complex
• interacts with RYBP, HIP2, TFCP2.
• association to chromosomal DNA is cell-cycle dependent

Structure

contains 1 RING-type Zn+2 finger

Compartment

• nucleus
• enriched on inactive X chromosome

More general terms

• E3 ubiquitin ligase
• ring finger protein
• nuclear protein
• phosphoprotein

Component of

• Polycomb group multiprotein PRC1 complex (PcG PRC1 complex, hPRC-H, PcG repressive complex 1)
• E2F6.com-1 complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6045
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6045
• OMIM: https://mirror.omim.org/entry/608985
• UniProt: http://www.uniprot.org/uniprot/Q99496.html