RING1 & YY1-binding protein (death effector domain-associated factor, DED-associated factor, YY1 & E4TF1-associated factor 1, apoptin-associating protein 1, APAP-1, RYBP, DEDAF, YEAF1)

Function

• regulation of transcription
• repressor of transcriptional activity of E4TF1
• in tumor cell lines, may induce apoptosis
• interacts with CBX2, YAF2, RING1 & RNF2
• interacts with apoptin, DEDD, FADD, CASP8, CASP10, YY1 & E4TF1B
• together with E4TF1B & YY1, forms ternary complex

Structure

• contains 1 RanBP2-type zinc finger

Compartment

• nucleus, cytoplasm, primarily found in nucleus

Expression

• widely expressed with highest levels in lymphoid tissues & placenta

More general terms

• zinc finger protein
• nuclear protein

Database

• OMIM: https://mirror.omim.org/entry/607535
• UniProt: http://www.uniprot.org/uniprot/Q8N488.html