death effector domain-containing protein (death effector domain-containing testicular molecule, DEDPro1, FLDED-1, DEDD, DEDPRO1, DEFT, KE05)

Function

• scaffold protein that directs CASP3 to certain substrates
  • facilitates their ordered degradation during apoptosis
• a role in CASP3 cleavage of KRT18
• a role in degradation of intermediate filaments during apoptosis
• a role in general transcription machinery in the nucleus
• regulates activity of GTF3C3 (putative)
• inhibits DNA transcription in vitro
• interacts with CASP8, CASP10, KRT8, KRT18, CASP3, FADD
• homodimerizes & heterodimerizes with DEDD2
• exists predominantly in a mono- or diubiquitinated form

Compartment

• cytoplasm
• translocates to the nucleus during CD95-mediated apoptosis, localizes in the nucleoli
• following apoptosis induction, the mono &/or diubiquitination form increases & forms filamentous structures that colocalize with KRT8 & KRT18 intermediate filament network in simple epithelial cells

Alternative splicing

named isoforms=2

Expression

• widely expressed with highest levels in testis

More general terms

• other protein

Additional terms

• DNA-binding death effector domain-containing protein 2 (FADD-like anti-apoptotic molecule 3, DED-containing protein FLAME-3, DEDD2, FLAME3, PSEC0004)

Database

• OMIM: https://mirror.omim.org/entry/606841
• UniProt: http://www.uniprot.org/uniprot/O75618.html