caspase-8; ICE-like apoptotic protease 5; MACH; MORT-1 associated CED-3 homolog; FLICE; FADD-like ICE; Mch5 (CASP8)

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Introduction

Multiple isoforms; 2 subunits: p18 & p10.

Function

Structure

Compartment

cytoplasm

Alternative splicing

named isoforms=9

Expression

Pathology

Polymorphism

Notes

More general terms

References

  1. Boldin MP, Goncharov TM, Goltsev YV, Wallach D. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death. Cell. 1996 Jun 14;85(6):803-15. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8681376
  2. Muzio M, Chinnaiyan AM, Kischkel FC, O'Rourke K, Shevchenko A, Ni J, Scaffidi C, Bretz JD, Zhang M, Gentz R, Mann M, Krammer PH, Peter ME, Dixit VM. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex. Cell. 1996 Jun 14;85(6):817-27. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8681377
  3. 3.0 3.1 Teitz T, Wei T, Valentine MB, Vanin EF, Grenet J, Valentine VA, Behm FG, Look AT, Lahti JM, Kidd VJ. Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN. Nat Med. 2000 May;6(5):529-35. PMID: https://www.ncbi.nlm.nih.gov/pubmed/10802708
  4. CASP8base, CASP8 mutation db http://bioinf.uta.fi/CASP8base/
  5. GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=CASP8
  6. UniProt http://www.uniprot.org/uniprot/Q14790.html

Database