caspase-7; ICE-like apoptotic protease 3; ICE-LAP3; Mch-3 protein (CASP7, MCH3)

Function

• role in the activation cascade of caspases responsible for apoptosis execution
• cleaves sterol regulatory element binding proteins (SREBPs) & activates them
• proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-gly-217' bond
• cleavages by granzyme B or caspase-10 generate the two active subunits
• propeptide domains can also be cleaved efficiently by caspase-3
• strict requirement for an Asp residue at position P1 & has a preferred cleavage sequence of Asp-Glu-Val-Asp-|-

Inhibition: inhibited by isatin sulfonamides

Structure

• active heterodimers between the small subunit of caspase-7 & the large subunit of caspase-3, & vice versa, also occur
• overexpression promotes programmed cell death heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kD (p20) & a 11 kD (p11) subunit
• belongs to the peptidase C14 family

Compartment

cytoplasm

Alternative splicing

named isoforms=3

Expression

• expressed in lung, skeletal muscle, liver, kidney, spleen & heart > testis
• no expression in brain

More general terms

• caspase

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:840
• OMIM: https://mirror.omim.org/entry/601761
• UniProt: http://www.uniprot.org/uniprot/P55210.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=840
• Kegg: http://www.genome.jp/dbget-bin/www_bget?