DNA-binding death effector domain-containing protein 2 (FADD-like anti-apoptotic molecule 3, DED-containing protein FLAME-3, DEDD2, FLAME3, PSEC0004)

Function

• role in death receptor-induced apoptosis
• may target CASP8 & CASP10 to the nucleus
• may regulate degradation of intermediate filaments during apoptosis
• role in general transcription machinery in the nucleus
• regulates activity of GTF3C3 (putative)
• interacts with CASP8, CASP10, GTF3C3
  • homodimerizes & heterodimerizes with DEDD

Structure

• contains 1 DED damain (death effector domain) interactions with CASP8 & CASP10 are mediated by the DED domain

Compartment

• nucleus
• accumulates in subnuclear structures resembling nucleoli

Alternative splicing

named isoforms=2

Expression

• expressed in most tissues
• high levels found in liver, kidney, heart, ovary, spleen, testes, skeletal muscle, peripheral blood leukocytes
• expression absent or low in colon, small intestine

Pathology

• expression is variable in tumor cell lines

More general terms

• DNA-binding protein

Additional terms

• death effector domain-containing protein (death effector domain-containing testicular molecule, DEDPro1, FLDED-1, DEDD, DEDPRO1, DEFT, KE05)

Database

• UniProt: http://www.uniprot.org/uniprot/Q8WXF8.html