E3 ubiquitin-protein ligase RING1; RING finger protein 1; polycomb complex protein RING1 (RING1, RNF1)

Function

• one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of Lys-119 of histone H2A, thereby playing a central role in histone code & gene regulation
• H2A Lys-119 ubiquitination gives a specific tag for epigenetic transcriptional repression & participates in X chromosome inactivation of female mammals
• component of polycomb group (PcG) multiprotein PRC1 complex
• compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, & it may rather act as a modulator of RNF2/RING2 activity
• protein modification; protein ubiquitination
• part of the E2F6.com-1 complex
• interacts with CBX2 & PCGF6
• component of repressive PcG BCOR complex

Structure

contains 1 RING-type Zn+2 finger

Compartment

nucleus speckle

Alternative splicing

named isoforms=2

More general terms

• phosphoprotein
• E3 ubiquitin ligase
• nuclear protein
• ring finger protein

Component of

• Polycomb group multiprotein PRC1 complex (PcG PRC1 complex, hPRC-H, PcG repressive complex 1)
• Polycomb group multiprotein BCOR complex (PcG BCOR complex)
• E2F6.com-1 complex

Database

• UniProt: http://www.uniprot.org/uniprot/Q06587.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6015
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6015
• OMIM: https://mirror.omim.org/entry/602045