X chromosome inactivation

Physiology

• X chromosome inactivation in females (epigenetic event)
  • enzymatic facilitation by
    • E3 ubiquitin-protein ligase RING1
    • E3 ubiquitin-protein ligase RING2
  • transcription repressor CTCF may participate in formation of an epigenetic switch for X chromosome inactivation
  • histone proteins with role in facilitation
    • histone H2A type 1-A
    • histone H2A type 1-C
    • histone H2A type 1-D
    • histone H2A 1-H
    • histone H2A type 2-A
    • histone H2A type 2-B
    • histone H2A type 2-C
    • histone H2A type 3
    • histone H2A type 1
    • histone H2A type 1-B/E
    • histone H2A type 1-J
    • core histone macro-H2A.1
    • core histone macro-H2A.2
• KDM6A escapes X chromosome inactivation

More general terms

• cytogenetics

Additional terms

• human X-chromosome