core histone macro-H2A.2 (Histone macroH2A2, mH2A2) (H2AFY2 MACROH2A2)

Function

• variant histone H2A
• replaces conventional H2A in a subset of nucleosomes where it represses transcription
• may be involved in stable X chromosome inactivation

Structure

• contains 1 histone H2A domain
• contains 1 Macro domain

Compartment

• nucleus
• enriched in inactive X chromosome chromatin & in senescence- associated heterochromatin

More general terms

• histone-H2A

Database

• UniProt: http://www.uniprot.org/uniprot/Q9P0M6.html