histone H2A type 1-D; H2A.3 (HIST1H2AD, H2AFG)

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Function

core component of nucleosome
chromatin-associated form is phosphorylated on Thr-120 during mitosis (putative)
deiminated on Arg-3 in granulocytes upon Ca+2 entry
monoubiquitination of Lys-119 by RING1 & RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression & plays a role in X chromosome inactivation (females)
role in initiation of both imprinted & random X inactivation
ubiquitinated H2A is enriched in inactive X chromosome
ubiquitination of H2A functions downstream of methylation of Lys-27s of histone H3
monoubiquitination of Lys-119 by RNF2/RING2 can be induced by ultraviolet light & may play a role in DNA repair
phosphorylation on Ser-1 is enhanced during mitosis
phosphorylation on Ser-1 by RPS6KA5/MSK1 directly represses transcription
acetylation of H3 inhibits Ser-1 phosphorylation by RPS6KA5/MSK1.
symmetric dimethylation on Arg-3 by PRDM1/PRMT5 complex involved in germ-cell lineage (putative)