Polycomb group multiprotein BCOR complex (PcG BCOR complex)

Function

• maintenance of transcriptionally repressive state of genes including BCL6, CDKN1A
• targeted to DNA by BCL6
• role in PKC signaling pathway (putative)
• represses CDKN1A expression by binding to its promoter, (RARE element dependent)
• promotes cell cycle progression
• enhances cell proliferation

Structure

• subunits: RYBP, RING1, RING2, PCGF1

Pathology

• role in tumor cell growth by down-regulating CDKN1A (putative)

More general terms

• molecular complex
• transcriptional silencer (transcriptional repressor)

Additional terms

• polycomb group protein (PcG)