B-cell lymphoma 6 protein; BCL-6; zinc finger protein 51; LAZ-3 protein; BCL-5; zinc finger & BTB domain-containing protein 27 (BCL6, BCL5, LAZ3, ZBTB27, ZNF51)
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Function
- transcriptional repressor required for germinal center formation & antibody affinity maturation
- phosphorylated by MAPK1 in response to antigen receptor activation
- Ser phosphorylation induces its degradation by ubiquitin/proteasome pathway
- interacts with ZBTB7 & BCL6B (putative)
- interacts with the catalytic domain of HDAC9
Structure
- contains 1 BTB/POZ domain
- contains 6 C2H2-type Zn+2 fingers
Compartment
Expression
- expressed in germinal center T & B cells & in primary immature dendritic cells
- down-regulated during maturation of dendritic cells by selective stimuli such as LPS, CD40L & zymosan
- CD40 activation & antigen stimulation downregulate bcl-6
Pathology
- role in lymphomagenesis (putative)
- chromosomal translocation t(3;14)(q27;q32) involving BCL6 with immunoglobulin gene regions may be a cause of B-cell non-Hodgkin lymphoma
- chromosomal translocation t(3;11)(q27;q23) involving BCL6 with POU2AF1/OBF1 may be a cause of a form of B-cell leukemia
- chromosomal translocation t(3;4)(q27;p11) involving BCL6 with ARHH/RhoH may be a cause of non-Hodgkin lymphoma
Laboratory
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P41182.html
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=603
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=604
- ↑ Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org/genes/BCL6ID20.html