zinc finger & BTB domain-containing protein 7A; factor binding IST protein 1; FBI-1; factor that binds to inducer of short transcripts protein 1; HIV-1 1st-binding protein 1; Leukemia/lymphoma-related factor; POZ & Krueppel erythroid myeloid ontogenic factor; POK erythroid myeloid ontogenic factor; Pokemon; TTF-I-interacting peptide 21; TIP21; zinc finger protein 857A (ZBTB7A, FBI1, LRF, ZBTB7, ZNF857A)
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Function
- plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive notch signals (putative)
- specifically represses the transcription of the CDKN2A gene
- efficiently abrogates E2F1-dependent CDKN2A transactivation/ de-repression
- binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' (putative)
- interacts with BCL6 (putative)
Structure
- contains 1 BTB/POZ domain
- contains 4 C2H2-type Zn+2 fingers
Compartment
Expression
- widely expressed
- in normal thymus, expressed in medullary epithelial cells & Hassle's corpuscles (at protein level)
- in tonsil, expressed in squamous epithelium & germinal center lymphocytes (at protein level)
- up-regulated in a subset of lymphomas, as well as in a subset of breast, lung, colon, prostate & bladder carcinomas (at protein level)