huntington-interacting protein 2; ubiquitin-conjugating enzyme E2-25 kDa (HIP2, UBE2K)

Function

• catalyzes covalent attachment of ubiquitin to other proteins
• degradation of short-lived & abnormal proteins
• ubiquitinates huntingtin
• foam cell formation by suppression of apoptosis of lipid-bearing macrophages via ubiquitination & degradation of p53.

Compartment

cytoplasm

Alternative splicing

named isoforms=2

Expression

• expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, T-lymphocytes, monocytes, granulocytes & bone marrow mononuclear cells
• highly expressed in brain, cortex, striatum > cerebellum, brainstem
• induced by aggregated low-density lipoprotein

More general terms

• ubiquitin-conjugating protein E2 (ubiquitin carrier protein)

Additional terms

• ubiquitin (UBCEP2, UBB, UBC)

Database

• OMIM: https://mirror.omim.org/entry/602846
• UniProt: http://www.uniprot.org/uniprot/P61086.html