RNA polymerase 2 140 kD subunit (RPB2, RNA polymerase 2 subunit B, RNA polymerase 2 subunit 2, POLR2B)

Function

• 2nd largest subunit of RNA polymerase 2
• forms the polymerase active center together with POLR2A
• initial binding of ribonucleoside triphosphates seems to occur at the entry (E) site & involves a Mg+2 coordinated by 3 conserved Asp of the two largest RNA polymerase 2 subunits, POLR2A & POLR2B (putative)

Structure

belongs to the RNA polymerase beta chain family

Compartment

nucleus

More general terms

• RNA polymerase L
• zinc finger protein

Component of

• RNA polymerase-2

Database

• UniProt: http://www.uniprot.org/uniprot/P30876.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5431
• OMIM: https://mirror.omim.org/entry/180661