Achaete-scute homolog 2; ASH-2; hASH2; mash2; class A basic helix-loop-helix protein 45; bHLHa45 (ASCL2, BHLHA45 HASH2)

Function

• AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system & the central nervous system
• efficient DNA binding requires dimerization with another bHLH protein

Structure

• contains 1 basic helix-loop-helix (bHLH) domain

Compartment

• nucleus

Expression

• expressed specifically in the extravillous trophoblasts of the developing placenta

More general terms

• achaete scute homolog

Additional terms

• Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein, ASH2L)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=430
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:430
• OMIM: https://mirror.omim.org/entry/601886
• UniProt: http://www.uniprot.org/uniprot/Q99929.html