histone-lysine N-methyltransferase SETD2 (SET domain-containing protein 2, hSET2, Huntingtin-interacting protein HYPB, Huntingtin yeast partner B, Huntingtin-interacting protein 1, HIF-1, p231HBP, SETD2, HIF1, HYPB, KIAA1732, SET2, HSPC069)
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Function
- histone methyltransferase
- methylates Lys-36 of histone H3.
- histone H3 Lys-36 methylation represents a specific tag for epigenetic transcriptional activation
- role in chromatin structure modulation during elongation via interaction with hyperphosphorylated POLR2A (putative)
- binds DNA at promoters
- transcription activator that binds to promoters
- interacts with hyperphosphorylated C-terminal domain (CTD) of RNA polymerase 2 large subunit (POLR2A)
- binds specifically to CTD heptad repeats doubly phosphorylated on Ser-2 & Ser-5 of each heptad
- interacts with HD
- low charge region mediates transcriptional activation
- automethylated (putative)
S-adenosyl-L-methionine + histone L-lysine
<-->
S-adenosyl-L-homocysteine + histone 6-N-methyl-L-lysine
Structure
- belongs to the histone-lysine methyltransferase family, SET2 subfamily
- contains 1 AWS domain
- contains 1 post-SET domain
- contains 1 SET domain
- contains 1 WW domain
Compartment
Alternative splicing
named isoforms=3
Expression
ubiquitously expressed
Pathology
- binds to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression
More general terms
Additional terms
- huntingtin-interacting protein 1; HIP-1 (HIP1)
- Huntington's disease [HD] protein (huntingtin) or IT15 protein