major facilitator superfamily (MFS)

Introduction

One of 2 major families of transporter that occurs ubiquitously in all organisms. The MFS transporters are single polypeptide multiple transmembrane domain carriers capable of transporting small molecules in response to ionic gradients.

More general terms

• adenosine triphosphatase (ATPase)
• carrier protein (transporter)
• membrane protein

More specific terms

• chromaffin granule amine transporter; vesicular amine transporter 1; VAT1; solute carrier family 18 member 1 (SLC18A1, VAT1, VMAT1)
• disrupted in renal carcinoma protein 2 (DIRC2)
• glucose-6-phosphate translocase; glucose-5-phosphate transporter; solute carrier family 37 member 4 (SLC37A4, G6PT, G6PT1, PRO0685)
• major facilitator superfamily domain-containing protein (MFSD)
• major facilitator superfamily domain-containing protein 8 (ceroid-lipofuscinosis neuronal protein 7, MFSD8, CLN7)
• major facilitator superfamily domain-containing protein 9 (MFSD9)
• major facilitator superfamily domain-containing protein LOC388931 (MFSD2B)
• MFS-type transporter C19orf28 (MFSD12)
• MFS-type transporter SLC18B1; solute carrier family 18 member B1 (SLC18B1, C6orf192)
• monocarboxylate transporter 11 (MCT 11, solute carrier family 16 member 11, SLC16A11, MCT11)
• monocarboxylate transporter 12 (MCT 12, solute carrier family 16 member 12, SLC16A12, MCT12)
• monocarboxylate transporter 13 (MCT 13, solute carrier family 16 member 13, SLC16A13, MCT13)
• monocarboxylate transporter 14 (MCT 14, solute carrier family 16 member 14, SLC16A14, MCT14)
• monocarboxylate transporter 7; MCT 7; solute carrier family 16 member 6 (SLC16A6, MCT7)
• monocarboxylate transporter 9 (MCT 9, solute carrier family 16 member 9, SLC16A9, MCT9, C10orf36)
• Na+ dependent phosphate transport protein 3; Na+/phosphate cotransporter 3; Na+/PI cotransporter 3; solute carrier family 17 member 2 (SLC17A2, NPT3)
• Na+-dependent glucose transporter 1 (NAGLT1, KIAA1919, HSPC100)
• Na+-dependent phosphate transport protein 1; Na+/phosphate cotransporter 1; Na+/PI cotransporter 1; solute carrier family 17 member 1; renal Na+-dependent phosphate transport protein 1; renal Na+-phosphate transport protein 1; renal Na+-dependent phosp...
• Na+-dependent phosphate transport protein 4; Na+/phosphate cotransporter 4; Na+/PI cotransporter 4; solute carrier family 17 member 3 (SLC17A3 NPT4)
• organic-cation transporter-like 4 (solute carrier family 22 member 14, SLC22A14, ORCTL4)
• protein spinster homolog 1 (spinster-like protein 1, HSpin1, SPNS1, SPIN1, PP20300)
• protein spinster homolog 2 (SPNS2)
• proton myo-inositol cotransporter (H+ myo-inositol cotransporter, Hmit, SLC2A13)
• proton-coupled folate transporter (heme carrier protein 1, PCFT/HCP1, solute carrier family 46 member 1, G21, SLC46A1, HCP1, PCFT)
• solute carrier family 16 member 2; monocarboxylate transporter 8; MCT 8; X-linked PEST-containing transporter (SLC16A2, MCT8, XPCT)
• solute carrier family 17 member 5 (SLC17A5, sialin, Na+/sialic acid cotransporter, sodium phosphate cotransporter, AST, membrane glycoprotein HP59)
• solute carrier family 17 member 9 (SLC17A9, C20orf59)
• solute carrier family 18 member 3 (SLC18A3, vesicular acetylcholine transporter, VAChT)
• solute carrier family 2 member 14 (SLC2A14, glucose transporter type 14, GLUT14)
• solute carrier family 2 member 7; glucose transporter type 7; GLUT-7 (SLC2A7 GLUT7)
• solute carrier family 2, facilitated glucose transporter member 12 (glucose transporter type 12, GLUT-12, SLC2A12, GLUT12, GLUT8)
• solute carrier family 22 member 11 (organic anion transporter 4, SLC22A11, OAT4)
• solute carrier family 22 member 17 (SLC22A17, brain-type organic cation transporter, BOCT, BOIT)
• solute carrier family 22 member 23; organic cation transporter protein C6orf85 (SLC22A23)
• solute carrier family 22 member 24 (SLC22A24)
• solute carrier family 22 member 2; organic cation transporter 2; hOCT2 (SLC22A2, OCT2)
• solute carrier family 22 member 3; organic cation transporter 3; extraneuronal monoamine transporter; EMT (SLC22A3, EMTH, OCT3)
• solute carrier family 22 member 4 (SLC22A4, organic cation/carnitine transporter 1, ergothioneine transporter, ET transporter, ETT, OCTN1, UT2H)
• solute carrier family 22 member 5; organic cation/carnitine transporter 2; high-affinity Na+-dependent carnitine cotransporter (SLC22A5, OCTN2)
• solute carrier family 22 member 8 (organic anion transporter 3, hOAT3, SLC22A8, OAT3)
• solute carrier family 22 member 9 (organic anion transporter 4, SLC22A9, OAT4, UST3)
• sugar phosphate exchanger 2 (solute carrier family 37 member 2, SLC37A2, SPX2)
• sugar phosphate exchanger 3 (solute carrier family 37 member 3, SLC37A3, SPX3)
• Synaptic vesicle 2-related protein (SV2-related protein) (SVOP)
• synaptic vesicular amine transporter; vesicular amine transporter 2; VAT2; monoamine transporter; solute carrier family 18 member 2 (SLC18A2, SVMT, VMAT2)
• transporter SVOPL (SVOP-like protein, SVOPL)
• urate anion exchanger 1 (solute carrier family 22 member 12, renal-specific transporter, RST, organic anion transporter 4-like protein, SLC22A12, OATL4, URAT1, UNQ6453/PRO34004)
• vesicular glutamate transporter 2 (VGluT2, solute carrier family 17 member 6, differentiation-associated Na+-dependent inorganic phosphate cotransporter, differentiation-associated BNPI, SLC17A6, DNPI, VGLUT2)