solute carrier family 16 member 2; monocarboxylate transporter 8; MCT 8; X-linked PEST-containing transporter (SLC16A2, MCT8, XPCT)

Function

• very active & specific thyroid hormone transporter
• stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) & diidothyronine
• does not transport Leu, Phe, Trp or Tyr (putative)

Structure

• belongs to the major facilitator superfamily monocarboxylate porter (TC 2.A.1.13) family

Compartment

cell membrane

Expression

highly expressed in liver & heart

Pathology

• defects in SLC16A2 are the cause of monocarboxylate transporter 8 deficiency

More general terms

• monocarboxylate transporter
• solute carrier family 16 (SLC16, SLC16A)
• glycoprotein
• phosphoprotein
• major facilitator superfamily (MFS)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6567
• OMIM: https://mirror.omim.org/entry/300095
• OMIM: https://mirror.omim.org/entry/300523
• UniProt: http://www.uniprot.org/uniprot/P36021.html