Na+-dependent phosphate transport protein 1; Na+/phosphate cotransporter 1; Na+/PI cotransporter 1; solute carrier family 17 member 1; renal Na+-dependent phosphate transport protein 1; renal Na+-phosphate transport protein 1; renal Na+-dependent phosphate cotransporter 1; Na/Pi-4 (SLC17A1, NPT1)

Function

• role in resorption of phosphate by the kidney
• role in actively transporting phosphate into cells via Na+ cotransport in the renal brush border membrane
• interacts with PDZK1 (putative)

Structure

• belongs to the major facilitator superfamily Na+/anion cotransporter family

Compartment

membrane

Alternative splicing

named isoforms=2

Expression

• expressed in renal cortex, liver & brain
• not expressed in other tissues

Notes

It is uncertain whether Met-1 or Met-3 is the initiator

More general terms

• major facilitator superfamily (MFS)
• Na+/phosphate cotransporter
• solute carrier family 17 (SLC17, SLC17A)

Database

• OMIM: https://mirror.omim.org/entry/182308
• UniProt: http://www.uniprot.org/uniprot/Q14916.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6568