urate anion exchanger 1 (solute carrier family 22 member 12, renal-specific transporter, RST, organic anion transporter 4-like protein, SLC22A12, OATL4, URAT1, UNQ6453/PRO34004)
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Function
- required for efficient urate re-absorption in the kidney
- regulates blood urate levels
- mediates saturable urate uptake by facilitating the exchange of urate against organic anions
- interacts with PDZK1
Structure
- belongs to the major facilitator superfamily, organic cation transporter family
Compartment
- cell membrane
- detected in the luminal membrane of the epithelium of renal proximal tubules
Alternative splicing
named isoforms=2
Expression
- detected in kidney (at protein level)
- detected in fetal & adult kidney
- detected in epithelial cells of proximal tubules in renal cortex
Pathology
- defects in SLC22A12 are a cause of renal hypouricemia
Pharmacology
- lesinurad (Zurampic) an inhibitor of URAT1 FDA-approved for treatment of gout in combination with xanthine oxidase inhibitor[2]
More general terms
- major facilitator superfamily (MFS)
- glycoprotein
- membrane protein
- solute carrier family 22 (SLC22, SLC22A)
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q96S37.html
- ↑ 2.0 2.1 FDA News Release. December 22, 2015 FDA approves Zurampic to treat high blood uric acid levels associated with gout. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm478791.htm